The Cleveland Guardians (65-56) and the San Diego Padres (68-57) wrap up a 2-game

interleague series at Petco Park. First pitch is scheduled for 4:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s 

lines around the Guardians vs. Padres odds with MLB picks and predictions. 

The Guardians registered a 3-1 victory in the series opener Tuesday as the bullpen pitched 4 1/3-scoreless 

IP of relief to help the visitors to the win. Cleveland looks to continue its success against 

left-handed starting pitchers, going 6-1 in the past 7 tries against southpaws. 

The Padres have really struggled scoring runs, totaling just 9 runs in the past five outings,  

going 2-3 during the span. Luckily the pitching staff has done a good job giving the team a chance,

allowing 3 or fewer runs in 4 of the past 5 contests. 

RHP Cal Quantrill vs. LHP Blake Snell Quantrill (9-5, 3.77 ERA) makes his 24th start. He has a 1.22 WHIP, 2.4 BB/9 and 5.8 K/9 in 136 IP.